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A new scanning system was designed based on a 3D printer to obtain profile measurements of the small fields (see figure 1c). The dose profiles were validated with multiple dosimetric approaches, including thin gap ion chambers, thimble chambers, radiochromic film and Faraday cups.

The scattering system was designed using analytical tools and confirmed with Monte Carlo (TOPAS) simulations (Figure 1a,b). The scattering system and collimation provides a focused beam allowing for the treatment of two mice in a row, reducing the necessary machine time. The cyclotron to target efficiency is upwards of 35%. To achieve such high dose rates with protons, we designed a new double scattering system for our experimental beamline to deliver a 228 MeV proton beam with a field size of 16 mm diameter. However, most experiments so far have been performed using electron irradiations.

The average dose rate compares favorably to the published literature.įLASH therapy (irradiations >100 Gy/s) promises to selectively spare healthy tissue. In conclusion, FLASH plans were designed and evaluated in the TPS with dose rate and scanning speed achievable by an IBA Proteus system leading to dose delivery timing compatible with published FLASH conditions. The resulting plans are compared to published results.

Using the spot delivery simulator and FLASH dedicated scorers implemented in the RayStation Monte Carlo dose engine, we evaluate and display FLASH metrics derived from voxel wise energy deposition time traces (0.1 ms resolution) such a dose rate vs. The delivery was in PBS mode using a SOBP modulated with a ridge filter and a range compensator for lateral modulation. Treatment plans for FLASH delivery were generated by interfacing a research version of the RayStation TPS (RaySearch Laboratories AB) with a software simulator of the IBA Proteus system (IBA S.A.). This high dose rate implies that the TPS must take into account the timing of spot delivery during plan design and evaluation. Flash irradiation involves irradiating tissue at high dose rate (typically above 40 Gy/s) in order to spare healthy tissue.

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